کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1363034 981501 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biological activities of retinoidal γ-hydroxybutenolides in cancer cell apoptosis and differentiation
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Biological activities of retinoidal γ-hydroxybutenolides in cancer cell apoptosis and differentiation
چکیده انگلیسی

Retinoidal γ-hydroxybutenolides 2a–d having various lengths of conjugated double bond were prepared in three steps from the corresponding aldehyde 4. Their biological activities were then measured. Of these compounds, only compound 2c possessing a structure similar to that of retinoic acid showed differentiation-inducing activity and very strong apoptosis-inducing activity in HL-60 cells.

Retinoidal γ-hydroxybutenolides having various lengths of conjugated double bond were prepared, and their apoptosis-inducing and differentiation-inducing activities were tested in HL-60 cells.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 13, Issue 21, 1 November 2005, Pages 6002–6008
نویسندگان
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