کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1363050 981502 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fmoc-protected iminosugar modified asparagine derivatives as building blocks for glycomimetics-containing peptides
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Fmoc-protected iminosugar modified asparagine derivatives as building blocks for glycomimetics-containing peptides
چکیده انگلیسی

CSF114(Glc) is the first synthetic Multiple Sclerosis Antigenic Probe able to identify autoantibodies in a statistically significant number of Multiple Sclerosis patients. The β-turn conformation of this glucopeptide is fundamental for a correct presentation of the epitope Asn(Glc). To verify the influence of sugar mimics in antibody recognition in Multiple Sclerosis, we synthesized Fmoc-protected Asn derivatives containing alkaloid-type sugar mimics. The corresponding glycomimetics-containing peptide derivatives of the CSF114-type sequence were tested in competitive and solid-phase non-competitive ELISA on Multiple Sclerosis patients’ sera.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 12, 15 June 2007, Pages 3965–3973
نویسندگان
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