کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1363056 | 981502 | 2007 | 22 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antimicrobial and cytotoxic activity of agelasine and agelasimine analogs
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Antimicrobial and cytotoxic activity of agelasine and agelasimine analogs Antimicrobial and cytotoxic activity of agelasine and agelasimine analogs](/preview/png/1363056.png)
چکیده انگلیسی
Agelasine and agelasimine derivatives with substantially less complicated terpenoid side chains compared to the naturally occurring compounds have been synthesized and their ability to inhibit growth of microorganisms and cancer cells has been studied. Compounds with excellent activity against cancer cell lines (MIC ca. 1 μM for the most potent compounds), including a drug resistant renal cell line, have been identified. Most compounds studied also exhibited broad spectrum antimicrobial activity including activity against Mycobacterium tuberculosis.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 12, 15 June 2007, Pages 4016–4037
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 12, 15 June 2007, Pages 4016–4037
نویسندگان
Anders Vik, Erik Hedner, Colin Charnock, Linda W. Tangen, Ørjan Samuelsen, Rolf Larsson, Lars Bohlin, Lise-Lotte Gundersen,