کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1363064 981502 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of 1,3-diphenyl-2-propen-1-one derivatives and evaluation of their biological activities
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of 1,3-diphenyl-2-propen-1-one derivatives and evaluation of their biological activities
چکیده انگلیسی

A simple synthesis and biological properties of 1,3-diphenyl-2-propen-1-ones 18–22 and 25–26 are described. The key synthetic strategies involve Grignard reaction of aldehyde 2 and oxidation reaction of 8–12 in high yields. The prepared compounds 18–22 and 25–26 were evaluated for free-radical scavenging, suppression of LPS-induced NO generation, and anti-excitotoxicity in vitro. It was found that a couple of compounds, especially 21 and 26, were potent suppressors of NO generation and demonstrated anti-excitotoxicity with the concentration range 10–20 μM in vitro.

A simple synthesis and biological properties of 1,3-diphenyl-2-propen-1-ones 18–22 and 25–26 are described.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 12, 15 June 2007, Pages 4098–4105
نویسندگان
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