کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1363098 | 981503 | 2005 | 7 صفحه PDF | دانلود رایگان |
A series of curcumin analogs (1–3, 5a–5t) was synthesized through the condensation of appropriately protected hydroxybenzaldehydes with acetylacetone, followed by deprotection. The antioxidant activity of these analogs was determined by superoxide free radical nitroblue tetrazolium and DPPH free radical scavenging methods and the polyhydroxycurcuminoids (5l–5s) displayed excellent antioxidant activity. These analogs showed cytotoxicity to lymphocytes and promising tumor-reducing activity on Dalton’s lymphoma ascites tumor cells.
A series of curcumin analogs was prepared from the appropriately substituted benzaldehydes. These analogs have displayed strong antioxidative and potent tumor reducing activities.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry - Volume 13, Issue 23, 1 December 2005, Pages 6374–6380