C3′-cis-Substituted carboxycyclopropyl glycines as metabotropic glutamate 2/3 receptor agonists: Synthesis and SAR studies

The synthesis of a series of C3′-cis-substituted carboxycyclopropyl glycines bearing a wide variety of functional groups is described, and the structure–activity relationship for this series as agonists of group II metabotropic glutamate receptors is reported.

The synthesis of a series of C3′-cis-substituted carboxycyclopropyl glycines bearing a wide variety of functional groups is described, and the structure–activity relationship for this series as agonists of group II metabotropic glutamate receptors is reported.Figure optionsDownload as PowerPoint slide