Design, synthesis, enzyme inhibition, and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors

A series of 2-anilinobenzamide derivatives were designed, synthesized and evaluated for their SIRT1-inhibitory activity. Among these, compounds 3 and 5 inhibited SIRT1 activity in enzyme assays and suppressed the growth of Daudi and HCT116 cells.

A series of 2-anilinobenzamide derivatives were designed and synthesized as SIRT1 inhibitors. In this series, compounds 3 and 5 showed SIRT1 inhibition in vitro and suppressed the growth of Daudi and HCT116 cells.Figure optionsDownload as PowerPoint slide