Novel mannosyl derivatives of peptidoglycan monomer: Synthesis and biological evaluation of immunomodulatory properties

The aim of this work was to prepare mannosyl derivatives of peptidoglycan monomer (PGM, β-d-GlcNAc-(1→4)-d-MurNAc-l-Ala-d-isoGln-mesoDAP(εNH2)-d-Ala-d-Ala) in order to study the effects of mannosylation on adjuvant (immunostimulating) activity. Novel Man-OCH2CH(CH3)CO–PGM isomers were substrates for N-acetylmuramyl-l-alanine amidase, like the parent PGM molecule. Adjuvant activity of Man-OCH2CH(CH3)CO–PGM was tested in the mouse model using ovalbumin as an antigen.

Novel mannosyl derivatives of peptidoglycan monomer were prepared in order to study the influence of the mannose moiety on the peptidoglycan’s immunomodulating activity in the mouse model.Figure optionsDownload as PowerPoint slide