کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1363241 | 981507 | 2007 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We have synthesized and assessed the ability of symmetrical fluorobenzoins and fluorobenzils to inhibit mammalian carboxylesterases (CE). The majority of the latter were excellent inhibitors of CEs however unexpectedly, the fluorobenzoins were very good enzyme inhibitors. Positive correlations were seen with the charge on the hydroxyl carbon atom, the carbonyl oxygen, and the Hammett constants for the derived Ki values with the fluorobenzoins.
The inhibition of mammalian carboxylesterases by fluorobenzoins and fluorobenzils has been evaluated. These studies demonstrated that the electronic charge on the central atoms impacts the biological activity of these molecules.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 11, 1 June 2007, Pages 3801–3817
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 11, 1 June 2007, Pages 3801–3817
نویسندگان
Latorya D. Hicks, Janice L. Hyatt, Teri Moak, Carol C. Edwards, Lyudmila Tsurkan, Monika Wierdl, Antonio M. Ferreira, Randy M. Wadkins, Philip M. Potter,