کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1363269 981508 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and molecular recognition of carbohydrate-centered multivalent glycoclusters by a plant lectin RCA120
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and molecular recognition of carbohydrate-centered multivalent glycoclusters by a plant lectin RCA120
چکیده انگلیسی

Water soluble and lectin-recognizable carbohydrate-centered glycoclusters were prepared efficiently by the Huisgen 1,3-cycloaddition reaction of methyl-2,3,4,6-tetra-O-propargyl β-d-galactopyranoside with 2-azidoethyl glycosides of lactose and N-acetyllactosamine. Their binding by a plant lectin RCA120 was examined by capillary affinity electrophoresis using fluorescence-labeled asialoglycans from human α1-acid glycoprotein. The glycoclusters showed 400-fold stronger inhibitory effect than free lactose, manifesting strong multivalency effect.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 13, Issue 22, 15 November 2005, Pages 6151–6157
نویسندگان
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