کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1363272 | 981508 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Preparation and anti-inflammatory activities of diarylheptanoid and diarylheptylamine analogs
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Seven diarylheptylamine (12a–g) and four diarylheptanoid analogs (3–5, 9), structurally related to the natural anti-inflammatory agent oregonin (1), have been prepared from curcumin (2) for evaluation of their activity against the expression of iNOS and COX-2. Diarylheptylamine 12b and diarylheptanoid analogs can inhibit iNOS and COX-2 responses of LPS, although less potently than 1. These compounds, however, possess stronger potency than 1 against COX-2-derived PGE2 formation, of which hexahydrocurcumin (4) is the most potent one with an IC50 value of 0.7 μM.
Analogs inhibit iNOS and COX-2 responses of LPS in macrophages and also exhibit marked inhibition of COX-2-derived PGE2 formation.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 13, Issue 22, 15 November 2005, Pages 6175–6181
Journal: Bioorganic & Medicinal Chemistry - Volume 13, Issue 22, 15 November 2005, Pages 6175–6181
نویسندگان
Su-Lin Lee, Wei-Jan Huang, Wan Wan Lin, Shoei-Sheng Lee, Chung-Hsiung Chen,