کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1363306 981509 2009 25 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Insecticidal heterolignans—Tubuline polymerization inhibitors with activity against chewing pests
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Insecticidal heterolignans—Tubuline polymerization inhibitors with activity against chewing pests
چکیده انگلیسی

Starting from natural product podophyllotoxin 1 substituted heterolignans were identified with promising insecticidal in vivo activity. The impact of substitution in each segment of the core structure was investigated in a detailed SAR study, and variation of substituents in both aromatic moieties afforded derivatives 5 and 43 with broad insecticidal activity against lepidopteran and coleopteran species. In vitro measurements supported by modeling studies indicate that heterolignans 3–134 act as tubuline polymerization inhibitors interacting with the colchicine-binding site. Insect specific structure–activity effects were observed showing that the insecticidal SAR described herein differs from reported cytotoxicity studies.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 17, Issue 12, 15 June 2009, Pages 4160–4184
نویسندگان
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