کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1363326 | 981510 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design, synthesis, and evaluation of indole compounds as novel inhibitors targeting Gp41
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Design, synthesis, and evaluation of indole compounds as novel inhibitors targeting Gp41 Design, synthesis, and evaluation of indole compounds as novel inhibitors targeting Gp41](/preview/png/1363326.png)
چکیده انگلیسی
A series of indole ring containing compounds were designed based on the structure of the gp41 complex in the region of the hydrophobic pocket. These compounds were synthesized using a Suzuki Coupling reaction, and evaluated using a fluorescence binding assay and cell–cell fusion assay. The observed inhibition constant of compound 7 was 2.1 μM, and the IC50 for cell–cell fusion inhibition was 1.1 μM. Assay data indicated that 7 is a promising lead compound for optimization into an effective low molecular weight fusion inhibitor.
Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 5, 1 March 2010, Pages 1500–1503
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 5, 1 March 2010, Pages 1500–1503
نویسندگان
Guangyan Zhou, Dong Wu, Evan Hermel, Edina Balogh, Miriam Gochin,