کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1363330 | 981510 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Discovery of a novel series of potent S1P1 agonists
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The discovery of a novel series of S1P1 agonists is described. Starting from a micromolar HTS positive, iterative optimization gave rise to several single-digit nanomolar S1P1 agonists. The compounds were able to induce internalization of the S1P1 receptor, and a selected compound was shown to be able to induce lymphopenia in mice after oral dosing.
The discovery of a novel series of S1P1 agonists is described. Several single-digit nanomolar S1P1 agonists were discovered, and a selected compound was shown to be able to induce lymphopenia in mice after oral dosing.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 5, 1 March 2010, Pages 1516–1519
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 5, 1 March 2010, Pages 1516–1519
نویسندگان
Stefano Crosignani, Agnes Bombrun, David Covini, Maurizio Maio, Delphine Marin, Anna Quattropani, Dominique Swinnen, Don Simpson, Wolfgang Sauer, Bernard Françon, Thierry Martin, Yves Cambet, Anthony Nichols, Isabelle Martinou,