Synthesis and evaluation of antioxidative properties of a series of organoselenium compounds

A series of organoselenocyanate compounds 4a–d were synthesized utilizing 1,8-naphthalic anhydride as the building unit. These compounds were evaluated for their antioxidative activities against DMBA–PMA-induced oxidative stress in a two-stage mouse skin carcinogenic model. Compound 4d was found to have the maximum antioxidative property in comparison with the other compounds. Also, the pretreatment group showed better results than the concomitant treatment groups.

A series of novel organoselenium compounds 4a–d were synthesized and these compounds were evaluated for their antioxidative activities against DMBA–PMA-induced oxidative stress in Swiss albino mice. The levels of lipid-peroxidation and phase II detoxifying enzymes were measured 15 days after the first DMBA application. Compound 4d was found to be the most active.Figure optionsDownload as PowerPoint slide