کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1363448 | 981512 | 2007 | 7 صفحه PDF | دانلود رایگان |

The chemical investigation of the Mediterranean ascidian Clavelina phlegraea has led to the isolation of six new 2-amino-3-alkanol derivatives, clavaminols A–F (1–6). Their stereostructures were established by analysis of spectroscopic data and chemical conversion. Clavaminols A, B, C, and F were tested for their cytotoxic and pro-apoptotic properties and clavaminol A was shown to be the more potent cytotoxic compound of this series inducing cell death through activation of the apoptotic machinery.
Clavaminols A–F (compounds 1–6) were isolated from the Mediterranean ascidian Clavelina phlegraea. Compound 1 was shown to be a cytotoxic compound inducing cell death through activation of the apoptotic machinery.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 8, 15 April 2007, Pages 2920–2926