کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1363448 981512 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clavaminols A–F, novel cytotoxic 2-amino-3-alkanols from the ascidian Clavelina phlegraea
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Clavaminols A–F, novel cytotoxic 2-amino-3-alkanols from the ascidian Clavelina phlegraea
چکیده انگلیسی

The chemical investigation of the Mediterranean ascidian Clavelina phlegraea has led to the isolation of six new 2-amino-3-alkanol derivatives, clavaminols A–F (1–6). Their stereostructures were established by analysis of spectroscopic data and chemical conversion. Clavaminols A, B, C, and F were tested for their cytotoxic and pro-apoptotic properties and clavaminol A was shown to be the more potent cytotoxic compound of this series inducing cell death through activation of the apoptotic machinery.

Clavaminols A–F (compounds 1–6) were isolated from the Mediterranean ascidian Clavelina phlegraea. Compound 1 was shown to be a cytotoxic compound inducing cell death through activation of the apoptotic machinery.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 8, 15 April 2007, Pages 2920–2926
نویسندگان
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