کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1363470 | 981513 | 2005 | 12 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Stereocontrolled synthesis of anticancer β-lactams via the Staudinger reaction Stereocontrolled synthesis of anticancer β-lactams via the Staudinger reaction](/preview/png/1363470.png)
Stereocontrolled synthesis of novel β-lactams using polyaromatic imines following the Staudinger reaction has been accomplished. The effects of domestic microwave irradiation on this type of reaction have been investigated. Formation of trans-β-lactams has been explained through isomerization of the enolates formed during the reaction of acid chloride (equivalent) with imines in the presence of triethylamine. A donor–acceptor complex pathway is believed to be involved in the formation of cis-β-lactams. The effect of a peri hydrogen has been found to be significant in controlling the stereochemistry of the resulting β-lactams. SAR has identified β-lactams with anticancer activity. The presence of an acetoxy group has proven obligatory for their anticancer activity.
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Journal: Bioorganic & Medicinal Chemistry - Volume 13, Issue 11, 1 June 2005, Pages 3611–3622