کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1363561 981515 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pyrrolidine amides of pyrazolodihydropyrimidines as potent and selective KV1.5 blockers
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Pyrrolidine amides of pyrazolodihydropyrimidines as potent and selective KV1.5 blockers
چکیده انگلیسی

Design and synthesis of pyrazolodihydropyrimidines as KV1.5 blockers led to the discovery of 7d as a potent and selective antagonist. This compound showed atrial selective prolongation of effective refractory period in rabbits and was selected for clinical development.

Design and synthesis of pyrazolodihydropyrimidines as KV1.5 blockers led to the discovery of 7d as a potent and selective antagonist. This compound showed atrial selective prolongation of effective refractory period in rabbits and was selected for clinical development.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 4, 15 February 2010, Pages 1436–1439
نویسندگان
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