کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1363785 | 981522 | 2006 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis and antitubercular activity of substituted phenylmethyl- and pyridylmethyl amines Synthesis and antitubercular activity of substituted phenylmethyl- and pyridylmethyl amines](/preview/png/1363785.png)
A total of 42 benzyl- and pyridylmethyl amines were synthesized either by reductive amination of aromatic/heteroaromatic aldehydes with amines or by conjugate addition of amines to the cinnamates followed by reduction of the ester group with lithium aluminium hydride to the respective propanolamines. All the synthesized compounds were evaluated against both avirulent and virulent strains of Mycobacterium tuberculosis. Many of the compounds exhibited MIC as low as 1.56 μg/mL. Few of potent compounds were also evaluated against clinical isolates of MDR TB and found to be active at one or other concentrations with MIC as low as 3.12 μg/mL.
A number of benzyl- and pyridylmethyl amines were synthesized and evaluated against Mycobacterium tuberculosis H37Rv strains. The potent compounds were evaluated against clinical isolates of MDR TB and found to be active at one or other concentrations. The MIC was found to be as low as 1.56 μg/mL.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 24, 15 December 2006, Pages 8186–8196