Design, synthesis and preliminary evaluation of new cinnamoyl pyrrolidine derivatives as potent gelatinase inhibitors

The FlexX docking of compound A8 with MMP. The synthesis and preliminary biological evaluation of cinnamoyl pyrrolidine derivatives as MMPs inhibitors are reported in this paper. Compound A8 showed the lowest IC50 at 5.2 nM, indicating that it might be a promising lead compound.