کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1363917 981524 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel antioxidant agents deriving from molecular combination of Vitamin C and NO-donor moieties
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Novel antioxidant agents deriving from molecular combination of Vitamin C and NO-donor moieties
چکیده انگلیسی

In this paper, we describe a new class of products in which NO-donor moieties are linked to either the 3-OH (4a–f) or 2-OH group (7a–c) of ascorbic acid (ASA). Log Ps and pKas of these products were experimentally evaluated. All the compounds were tested for their antioxidant activity on lipidic peroxidation induced by Fe3+-ADP/NADPH in lipids of microsomal membranes of rat hepatocytes. Only 3-O series displays antioxidant activity and it seems to be principally dependent on the lipophilicity. Both series trigger in vitro NO-dependent vasodilator properties.

A new class of products in which NO-donor moieties are linked to either the 3-OH or 2-OH group of ascorbic acid was synthesized. Their physico-chemical properties, antioxidant and vasodilator activities are discussed.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 9, 1 May 2008, Pages 5199–5206
نویسندگان
, , , , , , , , ,