کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1363962 981525 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and biological evaluation of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides: A class of potent aggrecanase-1 inhibitors
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and biological evaluation of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides: A class of potent aggrecanase-1 inhibitors
چکیده انگلیسی

The prevention of aggrecan (a key component of cartilage) cleavage via the inhibition of aggrecanase-1 may provide a unique opportunity to stop the progression of cartilage degradation in osteoarthritis. The evaluation of a series of biphenylsulfonamides resulted in the identification of the ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides analogs (19–21 and 24) with improved Agg-1 inhibition and MMP-2, MMP-13 activity.

A subset of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides were identified as potent Agg-1, MMP-2 and MMP-13 inhibitors through the synthesis of a series of (Phenoxy)methyl biphenylsulfonamide carboxylates.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 9, 1 May 2009, Pages 2487–2491
نویسندگان
, , , , , , , , , , , , , , ,