Synthesis of novel antitumoural analogues of dysidiolide from ent-halimic acid

Several sesterterpenolides analogues of dysidiolide have been synthesized and their in vitro antitumoural activity against human HeLa, A549, HT-29 and HL-60 carcinoma cells is presented. The proliferation inhibition data showed a significant antitumour activity of the compounds 1b, 2a, 2b, 3a, 3b, 4a, 4b, 5, inhibiting proliferation of distinct cancer cell types with an IC50 in the low micromolar range.

Several antitumoural analogues of Dysidiolide have been synthesised starting from ent-halimic acid.Figure optionsDownload as PowerPoint slide