کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1364244 | 981532 | 2007 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 5: 2′-Substituted 6-nitroquipazines
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
Five C2′-substituted 6-nitroquipazine (6-NQ) derivatives were prepared and evaluated in terms of their biological abilities (Ki) to displace [3H]citalopram binding to serotonin transporter. The relationship between their structure and biological activities revealed that shorter alkyl groups tend to possess higher binding affinity. Both compounds 12a and 12c were found to have the equally highest binding affinity (Ki = 0.43 ± 0.02 nM).
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 10, 15 May 2007, Pages 3499–3504
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 10, 15 May 2007, Pages 3499–3504
نویسندگان
Jae Hak Lee, Yong Hyun Choi, Yoo Jin Lim, Byoung Se Lee, Dae Yoon Chi, Changbae Jin,