کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1364296 981534 2006 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structure–activity-relationship studies of conformationally restricted analogs of combretastatin A-4 derived from SU5416
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Structure–activity-relationship studies of conformationally restricted analogs of combretastatin A-4 derived from SU5416
چکیده انگلیسی

A series of combretastatin A-4 analogs derived from the ATP competitive, VEGF receptor tyrosine kinase inhibitor, SU5416 were synthesized. The cytotoxic effects of the analogs were evaluated against PC-3 and MDA-MB-231 cancer cell lines, as well as their abilities to inhibit tubulin polymerization. Results are compared to those of compound 1, our lead compound previously reported.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 19, 1 October 2006, Pages 6492–6501
نویسندگان
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