کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1364299 981534 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The synthesis of l-carvone and limonene derivatives with increased antiproliferative effect and activation of ERK pathway in prostate cancer cells
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
The synthesis of l-carvone and limonene derivatives with increased antiproliferative effect and activation of ERK pathway in prostate cancer cells
چکیده انگلیسی

Thirty-one novel derivatives of carvone, carveol, and limonene were designed and synthesized using l-carvone as a starting material via chlorination, nucleophilic substitution, and reduction. The structures of these derivatives were characterized by MS and 1H NMR. The antiproliferative effect was evaluated in human prostate cancer LNCaP cells. l-Carvone, l-carveol, and l-limonene were weak cell growth inhibitors and introduction of 4-(2-methoxyphenyl)piperazine to carvone, carveol or limonene significantly increased their antiproliferative effect. The antiproliferative effect was correlated with ERK activation and p21waf1 induction.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 19, 1 October 2006, Pages 6539–6547
نویسندگان
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