کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1364306 981534 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of benzenepropanamine analogues as non-detergent spermicides with antitrichomonas and anticandida activities
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of benzenepropanamine analogues as non-detergent spermicides with antitrichomonas and anticandida activities
چکیده انگلیسی

Fifteen analogues of benzenepropanamine were synthesized and evaluated for their spermicidal as well as microbicidal activities against Trichomonas vaginalis and Candida spp. Several compounds showed appreciable dual activities. Compound 12 exhibited good spermicidal (MEC = 0.1%) along with substantial anticandidal (MIC = 0.05%) activities, while compounds 3 and 6 showed significant microbicidal activities with moderate spermicidal effect. The SAR of these structures is being discussed here in this communication. It is concluded that suitable structural modifications in this class of compounds at 3-amino position may lead to a potent spermicide with associated microbicidal activity.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 19, 1 October 2006, Pages 6593–6600
نویسندگان
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