Pyrrospirones A and B, apoptosis inducers in HL-60 cells, from an endophytic fungus, Neonectria ramulariae Wollenw KS-246

Pyrrospirones A and B have been isolated from unpolished rice cultures of the endophytic fungus Neonectria ramulariae Wollenw KS-246. Their absolute stereostructures (1 and 2) were elucidated through spectroscopic methods using 1D and 2D NMR techniques and chemical transformations, including the modified Mosher’s method. The compounds exhibited cytotoxicity and induced apoptosis in human promyelocytic leukemia HL-60 cells.

Pyrrospirones A and B have been isolated from the endophytic fungus Neonectria ramulariae Wollenw KS-246. The compounds exhibited cytotoxicity and induced apoptosis in human promyelocytic leukemia HL-60 cells.Figure optionsDownload as PowerPoint slide