کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1364367 981535 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design at the atomic level: Generation of novel hybrid biaryloxazolidinones as promising new antibiotics
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Design at the atomic level: Generation of novel hybrid biaryloxazolidinones as promising new antibiotics
چکیده انگلیسی

From the X-ray crystal structures of linezolid and the non-selective antibiotic sparsomycin, we have derived a new family of hybrid oxazolidinones. From this initial compound set we have developed a new biaryloxazolidinone scaffold that shows both potent antimicrobial activity as well as selective inhibition of ribosomal translation. The synthesis of these compounds is outlined.

From the X-ray crystal structures of linezolid and the non-selective antibiotic sparsomycin, we have derived a new family of hybrid oxazolidinones. From this initial compound set we have developed a new biaryloxazolidinone scaffold that shows both potent antimicrobial activity as well as selective inhibition of ribosomal translation. The synthesis of these compounds is outlined.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 23, 1 December 2008, Pages 6179–6183
نویسندگان
, , , , , , , , , , , , , , , , ,