In vitro efficiency of new acridyl derivatives against Plasmodium falciparum

A series of new 9-substituted acridyl derivatives were synthesized and their in vitro antimalarial activity was evaluated against one chloroquine-sensitive strain (3D7) and three chloroquine-resistant strains [W2 (Indochina), Bre1 (Brazil) and FCR3 (Gambia)] of Plasmodium falciparum. Some compounds inhibit the growth of malarial parasite with IC50 ⩽ 0.20 μM.

A series of new 9-substituted acridyl derivatives were synthesized and their in vitro antimalarial activity was evaluated against Plasmodium falciparum. Some compounds inhibit the growth of malarial parasite with IC50 ⩽ 0.20 μM.Figure optionsDownload as PowerPoint slide