8-Hydroxyquinoline derivatives induce the proliferation of rat mesenchymal stem cells (rMSCs)

A series of 8-hydroxyquinoline derivatives with different substituted groups at 2- or 5-position have been synthesized and characterized. Their effects on the proliferation of the rat marrow-derived mesenchymal stem cells (rMSCs) have been evaluated by MTT assay and flow cytometry. We also analyzed the ability of these compounds to regulate the proliferation of rMSCs and the relationship with the structures of 8-hydroxyquinoline. Compounds 8–11, in which, the vinyl-substituents are on the 2-position of 8-hydroxyquinoline, appear to be able to induce the proliferation of rMSCs. These results show that compounds 8–11 provide a kind of new substances for regulating the proliferation of rMSCs.

Effects of compounds 8–11 on the proliferation of rMSCs by MTT assay. Each bar represents means ± SD from five independent experiments. ∗ denotes values that are statistically significantly higher than control group.Figure optionsDownload as PowerPoint slide