کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1364580 981540 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development of novel tail-modified anandamide analogs
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Development of novel tail-modified anandamide analogs
چکیده انگلیسی

To explore the hydrophobic groove subsite within the CB1 cannabinoid receptor we have designed and synthesized a group of tail-substituted anandamide analogs. Our design involves the introduction of aryl or heterocyclic ring as terminal substituents that are connected to the last cis-arachidonyl double bond through aliphatic chains of variable lengths. Our results indicate that there are strict stereochemical requirements for the interaction of such analogs with the CB1 receptor. The optimal pharmacophore includes the phenyl, p-substituted phenyl, or 3-furyl substituents attached to the cis-double bond through a four methylene chain.

Synthesis and evaluation of a series of anandamide analogs of variable chain lengths in which the terminal carbon is functionalized with a phenyl, substituted phenyl or heterocyclic group.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 22, 15 November 2008, Pages 5912–5915
نویسندگان
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