کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1364690 981544 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Norbornyllactone-substituted xanthines as adenosine A1 receptor antagonists
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Norbornyllactone-substituted xanthines as adenosine A1 receptor antagonists
چکیده انگلیسی

During the search for second-generation adenosine A1 receptor antagonist alternatives to the clinical candidate 8-(3-oxa-tricyclo[3.2.1.02,4]oct-6-yl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione (BG9719), we developed a series of novel xanthines substituted with norbornyl-lactones that possessed high binding affinities for adenosine A1 receptors and in vivo activity.

During the search for second-generation adenosine A1 receptor antagonist alternatives to the clinical candidate 8-(3-oxa-tricyclo[3.2.1.02,4]oct-6-yl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione (BG9719), we developed a series of novel xanthines substituted with norbornyl-lactones that possessed high binding affinities for adenosine A1 receptors and in vivo activity.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 11, 1 June 2006, Pages 3654–3661
نویسندگان
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