کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1364787 981545 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development of mitochondria-targeted derivatives of resveratrol
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Development of mitochondria-targeted derivatives of resveratrol
چکیده انگلیسی

To target natural polyphenols to the subcellular site where their redox properties might be exploited at best, that is, mitochondria, we have synthesised new proof-of-principle derivatives by linking resveratrol (3,4′,5-trihydroxy-trans-stilbene) to the membrane-permeable lipophilic triphenylphosphonium cation. The new compounds, (4-triphenylphosphoniumbutyl)-4′-O-resveratrol iodide and its bis-acetylated derivative, the latter intended to provide transient protection against metabolic conjugation, accumulate into energized mitochondria as expected and are cytotoxic for fast-growing but not for slower-growing cells. They provide a powerful potential tool to intervene on mitochondrial and cellular redox processes of pathophysiological relevance.

Synthesis, mitochondriotropic behavior, and cytotoxicity of resveratrol-triphenylphosphonium conjugates.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 20, 15 October 2008, Pages 5594–5597
نویسندگان
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