Synthesis and immunostimulatory properties of the phosphorothioate analogues of cdiGMP

The synthesis of mono- and bisphosphorothioate analogues of 3′,5′-cyclic diguanylic acid (cdiGMP) via the modified H-phosphonate chemistry is reported. The immunostimulatory properties of these analogues were compared with those of cdiGMP.

The phosphorothioate analogues of cdiGMP were synthesized and their immunostimulatory properties were compared.Figure optionsDownload as PowerPoint slide