کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1364803 981545 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
DNA-templated click chemistry for creation of novel DNA binding molecules
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
DNA-templated click chemistry for creation of novel DNA binding molecules
چکیده انگلیسی

We have developed a new methodology for producing new molecules that bind to dsDNA using DNA-templated click chemistry. The click reactions between the minor groove binding peptide and acridine intercalators were accelerated by the addition of dsDNA. Furthermore, the resulting peptide–acridine conjugate showed a slightly stronger binding to dsDNA. These results indicate that the DNA-templated click chemistry is applicable for screening new binding molecules.

We have developed a new methodology for producing new molecules that bind to dsDNA using the DNA-templated click chemistry.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 20, 15 October 2008, Pages 5660–5663
نویسندگان
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