Safrole oxide induces apoptosis by up-regulating Fas and FasL instead of integrin β4 in A549 human lung cancer cells

Safrole reacted with 3-chloroperoxybenzoic acid (mCPBA) in chloroform or in benzene to yield 3,4-(methylenedioxy)-1-(2′,3′-epoxypropyl)-benzene (safrole oxide). Safrole oxide induced apoptosis in A549 human lung cancer cells perhaps through Fas/FasL pathway.