کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1365018 | 981550 | 2008 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Correlation between reduction potentials and inhibitions of Epstein–Barr virus activation by anthraquinone derivatives Correlation between reduction potentials and inhibitions of Epstein–Barr virus activation by anthraquinone derivatives](/preview/png/1365018.png)
As a continuation of studies using natural and synthetic products as cancer chemopreventive agents, we used cyclic voltammetry to examine the reduction–oxidation potentials of methylated emodin derivatives prepared from emodin in phosphate buffer at pH 7.2. A good correlation was found between the inhibitory effects on Epstein–Barr virus early antigen (EBV-EA) activation and the reduction potential of methylated emodin derivatives. Furthermore, there was significant correlation between EBV-EA activation and the reduction potential of 35 anthraquinone derivatives including methylated emodin derivatives. It was further shown that the correlation could be enhanced by including LUMO energy and the number of hydroxy groups as additional parameters.
The structure–activity relationships between the inhibitory effects (log IC50) and the first reduction potentials of anthraquinone derivatives are described.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 14, 15 July 2008, Pages 4106–4109