کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1365033 | 981550 | 2008 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Novel fluorinated acridone derivatives. Part 1: Synthesis and evaluation as potential anticancer agents Novel fluorinated acridone derivatives. Part 1: Synthesis and evaluation as potential anticancer agents](/preview/png/1365033.png)
We report on the synthesis of a novel series of fluorinated acridones from 5-trifluoromethyl-1,3-cyclohexanedione. The cytotoxic activities of the compounds were studied in several cancer cells. Compounds 9a, 9c, 9e, 9f, and 9h exhibited significant anticancer activities in selected cell lines. Compound 9c is the most active showing GI50 that ranged in values from 0.13 to 26 μM, covering a wide range of cancer cell lines.
We report on the synthesis of a novel series of fluorinated acridones from 5-trifluoromethyl-1,3-cyclohexanedione. The cytotoxic activities of the compounds were studied in several cancer cells. Compounds 9a, 9c, 9e, 9f, and 9h exhibited significant anticancer activities in selected cell lines. Compound 9c is the most active showing GI50 that ranged in values from 0.13 to 26 μM, covering a wide range of cancer cell lines.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 14, 15 July 2008, Pages 4172–4176