Synthesis, characterization, and in vivo skeletal localization of a new 99mTc-based multidentate phosphonate chelate: 5-Amino-1,3-bis(ethylamine-(N,N dimethyl diphosphonic acid) acetamido) benzene

The tetraphosphonate ligand, 5-amino-1,3-bis(ethylamine-(N,N-dimethyl diphosphonic acid) acetamido) benzene (IPTMP) used in the present study was prepared from 5-nitroisophthalate dimethylester to label with radionuclide for targeted diagnosis and therapy. The synthesized multidentate phosphonate ligand was characterized on the basis of spectroscopic techniques, which exhibited good metal ion control properties when complexed to 99mTc with high in vitro and in vivo stability. Excellent quality bone images of rabbit were imaged showing rapid clearance of background activity and visualization of skeleton at 1 h.

The compound 5-amino-1, 3-bis(ethylamine-(N,N-dimethyl diphosphonic acid) acetamido) benzene (IPTMP), was synthesized from 5-nitroisophthalate dimethyl ester and ethylenediamine, a new synthetic route of preparation of phosphonate based chelating agent, is described to obtain a more stable agent for radiodiagnosis and radiotherapy.Figure optionsDownload as PowerPoint slide