کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1365212 981554 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inhibitors of anthrax lethal factor based upon N-oleoyldopamine
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Inhibitors of anthrax lethal factor based upon N-oleoyldopamine
چکیده انگلیسی

The structural features of an anthrax lethal factor inhibitor, N-oleoyldopamine (OLDA, 1) have been probed. The oleic acid moiety is critical, but, more interestingly, the presence of the double bond and its geometry were found to play an essential role. One compound, 5, was found to be an uncompetitive inhibitor of lethal factor (LF) with a Ki value of 2.2 μM and a cell-based IC50 value of 4.3 μM.

The structural features of an anthrax lethal factor inhibitor, N-oleoyldopamine (OLDA) have been probed. The oleic acid moiety is critical, but, more interestingly, the presence of the double bond and its geometry were found to play an essential role.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 7, 1 April 2008, Pages 2467–2470
نویسندگان
, , ,