Synthesis, SAR studies, and pharmacological evaluation of 3-anilino-4-(3-indolyl) maleimides with conformationally restricted structure as orally bioavailable PKCβ-selective inhibitors

IC50 values (nM (at isozymes)): 4.0 (β1), 2.3 (β2), 86 (α), 110 (γ), 54 (δ), 490 (ε), 1700 (ζ), 1000 (μ)