کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1365307 | 981557 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design, synthesis, and biological evaluation of 1,2,3-trisubstituted-1,4-dihydrobenzo[g]quinoxaline-5,10-diones and related compounds as antifungal and antibacterial agents
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A series of (S)-N-(3-chloro-1,4-naphthoquinon-2-yl)-α-amino acid ethyl esters 3 and 1,2,3-trisubstituted-1,4-dihydrobenzo[g]quinoxaline-5,10-diones 6–23 were synthesized and evaluated for antifungal and antibacterial activities. The structure–activity relationship of these compounds was studied and the results show that the compounds 3a and 3b exhibited in vitro antifungal activity against Candida albicans, Cryptococcus neoformans, and Sporothrix schenckii whereas compounds 12 and 22 showed in vitro antibacterial activity against Klebsiella pneumoniae and Escherichia coli.
The synthesis, antifungal, and antibacterial activities of 3–23 are described.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 17, 1 September 2006, Pages 6120–6126
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 17, 1 September 2006, Pages 6120–6126
نویسندگان
Vishnu K. Tandon, Dharmendra B. Yadav, Hardesh K. Maurya, Ashok K. Chaturvedi, Praveen K. Shukla,