کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1365348 981560 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Conformationally constrained diketopimelic acid analogues as inhibitors of dihydrodipicolinate synthase
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Conformationally constrained diketopimelic acid analogues as inhibitors of dihydrodipicolinate synthase
چکیده انگلیسی

Dihydrodipicolinate synthase (DHDPS) is a key enzyme in lysine biosynthesis and a potential antibiotic target. The enzyme catalyses the condensation of (S)-aspartate semi-aldehyde (ASA) and pyruvate to form dihydrodipicolinate. Constrained diketopimelic acid derivatives have been designed as mimics of the acyclic enzyme-bound condensation product of ASA and pyruvate. Several of the compounds are shown to be active, slow-binding inhibitors with improved inhibition of DHDPS.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 2, 15 January 2008, Pages 460–463
نویسندگان
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