کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1365390 | 981560 | 2008 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Modifying the glycosidic linkage in digitoxin analogs provides selective cytotoxins Modifying the glycosidic linkage in digitoxin analogs provides selective cytotoxins](/preview/png/1365390.png)
A chemoselective reaction between oxyamines and unprotected, unactivated reducing sugars was used to construct for the first time a panel of linkage-diversified neoglycosides. This panel of digitoxin analogs included potent and selective tumor cytotoxins; cytotoxicity was dependent on the structure of the glycosidic linkage. These results validate linkage diversification through neoglycosylation as a unique and simple strategy to powerfully complement existing methods for the optimization of glycoconjugates.
For the first time a panel of linkage-diversified neoglycosides was constructed. This panel of digitoxin analogs included potent and selective tumor cytotoxins; cytotoxicity was dependent on the structure of the glycosidic linkage.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 2, 15 January 2008, Pages 670–673