کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1365506 981564 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design and evaluation of analogues of the bacterial cell-wall peptidoglycan motif l-Lys-d-Ala-d-Ala for use in a vancomycin biosensor
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Design and evaluation of analogues of the bacterial cell-wall peptidoglycan motif l-Lys-d-Ala-d-Ala for use in a vancomycin biosensor
چکیده انگلیسی

Four small molecular receptors of vancomycin have been designed to make part of a novel biosensor device based on the FTIR-ATR detection: N-Boc (2a) or N-Ac (2b)-6-aminocaproyl-d-Ala-d-Ala and N-Boc (3a) or N-Ac (3b)-6-aminocaproyl-d-Ala-d-Ser. Using an original microbiological approach to assess the competition of compounds with the natural target of vancomycin in bacteria, EC50 values of 6.3–8.0 × 10−5 M (2a–b) and 7.1–9.3 × 10−4 M (3a–b) were determined. Vancomycin:2b complex was characterized by MS.

Use of an original microbiological approach to assess competition of synthetic compounds with the natural target of vancomycin in bacteria.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 21, 1 November 2007, Pages 5758–5762
نویسندگان
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