کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1365550 | 981564 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design and synthesis of thiazole-5-hydroxamic acids as novel histone deacetylase inhibitors
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Design and synthesis of thiazole-5-hydroxamic acids as novel histone deacetylase inhibitors Design and synthesis of thiazole-5-hydroxamic acids as novel histone deacetylase inhibitors](/preview/png/1365550.png)
چکیده انگلیسی
We have designed and synthesized a series of structurally novel hydroxamic acid-based histone deacetylase (HDAC) inhibitors characterized by a zinc chelating head group attached directly to a thiazole ring. The thiazole ring connects to a piperazine spacer, which is capped with a sulfonamide group. These novel molecules potently inhibit an HDAC enzyme mixture derived from HeLa cervical carcinoma cells and show potent antiproliferative activity against the breast cancer cell line MCF7.
The synthesis, histone deacetylase (HDAC) inhibitory activity and the antiproliferative activity of thiazole-5-hydroxamic acids 6–9 are described.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 21, 1 November 2007, Pages 5995–5999
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 21, 1 November 2007, Pages 5995–5999
نویسندگان
Sampath-Kumar Anandan, John S. Ward, Richard D. Brokx, Trisha Denny, Mark R. Bray, Dinesh V. Patel, Xiao-Yi Xiao,