Recent developments in the identification of novel oxazolidinone antibacterial agents

The oxazolidinones are a promising new class of synthetic antibacterial agents. Here, we review recent efforts directed at the discovery of new antibacterial compounds of this class. New structures and structure–activity relationships (SAR) are discussed in the context of earlier work in the field. Key issues of potency, spectrum, selectivity, in vivo efficacy, and pharmacokinetic profile of the new analogs are addressed.

This review describes recent efforts directed at the discovery of new antibacterial oxazolidinones. New structures and structure–activity relationships (SARs) are discussed in the context of earlier work in the field.Figure optionsDownload as PowerPoint slide