Synthesis, metal complexation and biological evaluation of a novel semi-rigid bifunctional chelating agent for 99mTc labelling

A novel bifunctional chelating agent bearing an aromatic ring has been synthesised and characterised. This ligand formed well-defined oxorhenium complexes. The analogous 99mTcO-complex was obtained in an excellent yield with high radiochemical purity (>95%). The biodistribution of the 99mTc-complex after intravenous injection studied in normal rats showed that the activity was excreted mainly via renal-urinary pathway indicating its use for labelling peptides with 99mTc.

In this paper, we report a convenient synthesis of a novel semi-rigid bifunctional chelating agent, their complexes with rhenium (V) and the in vivo behaviour in normal rats of the corresponding 99mTcO-complex.Figure optionsDownload as PowerPoint slide