کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1365751 981572 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Syntheses of glucose analogues of E5564 as a highly potent anti-sepsis drug candidate
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Syntheses of glucose analogues of E5564 as a highly potent anti-sepsis drug candidate
چکیده انگلیسی
Glucose analogues 5 and 9 of E5564 were synthesized, and their LPS-antagonistic activities were measured. The inhibitory activities (IC50) on LPS-induced TNFα production of these two compounds towards human whole blood cells were 0.06 and 0.83 nM, respectively. Inhibitory doses (ID50) of compounds 5 and 9 on TNFα production induced by coinjection of galactosamine and LPS in C3H/HeN mice in vivo were measured and were 0.55 and <0.20 mg/kg, respectively. And also C3H/HeN mice preinjected with compounds 5 and 9 were protected from lethality induced by coinjection of galactosamine and LPS; out of eight mice preinjected with 1 mg/kg of the compounds, one-six and three of eight mice were protected, respectively.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 9, 1 May 2006, Pages 3011-3016
نویسندگان
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